Novel amino-terminal propeptide configuration in a fibrillar procollagen undergoing alternative splicing.
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چکیده
منابع مشابه
Procollagen type 1 amino-terminal propeptide: a marker for bone metastases in prostate carcinoma.
BACKGROUND The objective of this study was to assess the utility of the bone formation marker procollagen type 1 amino-terminal propeptide (P1NP) in indicating bone metastases in patients with prostate carcinoma. Alkaline phosphatase (AP) and prostate-specific antigen (PSA) were measured as a comparison. PATIENTS AND METHODS The serum samples of 100 patients were analysed using a specific imm...
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Carboxy-terminal propeptide of type I procollagen (PICP) is used as a marker of bone formation and, presumably, also peritoneal fibrosis. The aim of the present study was to assess the effect of dialysate PICP level (PICPd) on serum PICP level (PICPs). The study group consisted of 20 patients divided into two groups: group A consisted of 10 children without peritonitis, mean age 13.6 +/- 5 year...
متن کاملImmunoassay for intact amino-terminal propeptide of human type I procollagen.
We have developed quantitative immunoassays for the intact, trimeric amino-terminal propeptide of human type I procollagen (PINP) and its Col1 domain. Intact PINP was isolated from the pleural fluids of cancer patients by a combination of ion-exchange, gel-filtration, and reversed-phase chromatographies. The amino-terminal Col1 domain of PINP was isolated after bacterial collagenase treatment o...
متن کاملTotal procollagen type 1 amino-terminal propeptide (total P1NP) as a bone metastasis marker in gynecological carcinomas.
BACKGROUND The aim of this study was the investigation of the diagnostic value of the amino-terminal propeptide of type I collagen (P1NP) and the tumour markers, CA 15-3 and CA 125, in patients with breast and ovarian cancer. PATIENTS AND METHODS Serum levels of P1NP, CA 15-3 and CA 125 were analyzed using specific immunoassays. Baseline serum samples of 66 patients with metastatic breast can...
متن کاملSerum concentrations of carboxyl-terminal propeptide of type I procollagen, amino-terminal propeptide of type III procollagen, cross-linked carboxyl-terminal telopeptide of type I collagen, and their interrelationships in schoolchildren.
We report pediatric age- and sex-specific 95% reference intervals for procollagen type I C-terminal propeptide (PICP), the cross-linked C-terminal telopeptide of type I collagen (ICTP), and procollagen type III N-terminal propeptide (P3NP), measured in plasma from 302 schoolchildren (156 boys, 146 girls) ages 4-19 years. All three markers displayed a significant variation with age (ANOVA P < or...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1992
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)41940-0